Alpha-1 antitrypsin is a protein that is made in the liver. The liver releases this protein into the bloodstream. AAT protects the lungs so they can work normally. Without enough AAT, the lungs can be damaged, and this damage may make breathing difficult. AAT deficiency occurs in approximately 1 in 2,500 individuals and may be initially diagnosed as COPD or asthma.

Do I have to smoke to have this condition?

NO Alpha-1 antitrypsin deficiency is inherited in families in an autosomal codominant pattern.

How is alpha-1 antitrypsin deficiency diagnosed?

AATD can be diagnosed through testing of a small blood sample

Is AATD Curable or Treatable?

There is currently no cure. Treatment is available. The major goal of AATD management is preventing or slowing the progression of lung disease via bronchodilators, prompt treatment with antibiotics for upper respiratory tract infections & AAT replacement therapy.
For severe lung disease, lung transplantation may be an option.